Diagnostic delay of pulmonary nontuberculous mycobacterial infection in China
نویسندگان
چکیده
BACKGROUND Nontuberculous mycobacteria (NTM) infection is an emerging, but neglected public health concern in China. FINDINGS To investigate diagnostic delay of NTM diseases in China, we analyzed 91 patients with pulmonary NTM infection in ShandongProvince. The median diagnostic delay time of the analyzed patients was 84 days, which was significantly associated with rural inhabitance (135 days vs. 73 days of urban inhabitance, p < 0.01) and lower level of first visiting hospitals/clinics (70 and 82 days of tertiary and secondary hospitals/clinics respectively vs. 120 days of primary hospitals/clinics, p < 0.05). M. farcinogenes was isolated from a 79-year-old male patient, which is the first report of pulmonary infection in humans. CONCLUSIONS Our results indicate a significant diagnostic delay of NTM diseases in China, especially for rural patients with limited access to higher-level healthcare services.
منابع مشابه
Mycobacterium tuberculosis Dominance over Nontuberculous Mycobacteria Irrespective of Immune Status: An Indian Scenario
Introduction: In HIV-associated tuberculosis cases, identifying nontuberculous Mycobacteria (NTM) from clinical samples has become essential regarding patients’ treatment and prognosis. This study aims to determine the prevalence of different Mycobacteria species from immunocompromised and immunocompetent patients with suspected tuberculosis attending a tertiary care hospital in Kolkata, India....
متن کاملAdjuvant surgical treatment of nontuberculous mycobacterial lung disease.
BACKGROUND According to the 2007 American Thoracic Society/Infectious Diseases Society of America statement on nontuberculous mycobacterial diseases, more evidence for the benefits of adjuvant nontuberculous mycobacterial lung disease surgical intervention is needed before its wide application can be recommended. METHODS A retrospective review was conducted of 60 consecutive patients who met ...
متن کاملGuidelines for chemotherapy of pulmonary nontuberculous mycobacterial disease--2012 revised version.
In 2008, the Nontuberculous Mycobacteriosis Control Committee of the Japanese Society for Tuberculosis and the Scientifi c Assembly for Infection and Tuberculosis of the Japanese Respiratory Society (hereinafter, the Joint Guidelines Committee) published the Guidelines for chemotherapy of pulmonary nontuberculous mycobacterial disease─2008 interim guidelines 1). In the background, rifabutin (RB...
متن کاملMycobacterial ocular inflammation: delay in diagnosis and other factors impacting morbidity.
IMPORTANCE The reported outcomes of ocular mycobacterial infection are commonly unfavorable. This study is among the first to elucidate factors associated with poor outcomes, as well as highlight the continued controversies in therapy, particularly the role of oral corticosteroids. OBJECTIVE To describe presentations and outcomes of mycobacterial ocular disease in the Midwestern United States...
متن کاملExtraction and biological evaluation of Mycobacterium kansasii extracellular vesicles as a vaccine candidate against mycobacterial pulmonary infections
Introduction: Extracellular vesicles (EVs) are bacterial products with diverse biological roles. Like many microorganisms, Mycobacterium kansasii as a nontuberculous mycobacteria (NTM), can naturally release EVs. The aim of the present study was the extraction and biological evaluation of M. kansasii as a vaccine candidate against mycobacterial pulmonary infections. Methods: After bacterial cul...
متن کامل